TEGRETOL 200MG 5X10

Thông tin sản phẩm

[{"title": "Th\u00e0nh ph\u1ea7n", "content": "

Carbamazepine 200mg

M\u1ed9t s\u1ed1 hàm l\u01b0\u1ee3ng và d\u1ea1ng bào ch\u1ebf có th\u1ec3 không có s\u1eb5n \u1edf t\u1ea5t c\u1ea3 các n\u01b0\u1edbc.

Tá d\u01b0\u1ee3c

Viên nén: Aerosil 200 (silic d\u1ea1ng keo khan), Avicel PH 101 (cellulose), magnesi stearat, Nymcel ZSB - 10 thay \u0111\u1ed5i (carmellose nattri, th\u1ec3 ít).

", "index": 1}, {"title": "C\u00f4ng d\u1ee5ng", "content": "", "index": 2}, {"title": "T\u00e1c d\u1ee5ng ph\u1ee5", "content": "

Tóm t\u1eaft v\u1ec1 h\u1ed3 s\u01a1 an toàn

\u0110\u1eb7c bi\u1ec7t lúc kh\u1edfi \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb b\u1eb1ng Tegretol, ho\u1eb7c n\u1ebfu li\u1ec1u kh\u1edfi \u0111\u1ea7u quá cao, ho\u1eb7c khi \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nhân cao tu\u1ed5i, m\u1ed9t s\u1ed1 lo\u1ea1i ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i r\u1ea5t th\u01b0\u1eddng g\u1eb7p ho\u1eb7c th\u01b0\u1eddng g\u1eb7p, ví d\u1ee5 các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u1edf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng (chóng m\u1eb7t, nh\u1ee9c \u0111\u1ea7u, m\u1ea5t \u0111i\u1ec1u hòa, bu\u1ed3n ng\u1ee7, m\u1ec7t m\u1ecfi, song th\u1ecb); các r\u1ed1i lo\u1ea1n tiêu hóa (bu\u1ed3n nôn, nôn) và ph\u1ea3n \u1ee9ng d\u1ecb \u1ee9ng da.

Các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i liên quan v\u1edbi li\u1ec1u dùng th\u01b0\u1eddng gi\u1ea3m trong vòng vài ngày m\u1ed9t cách t\u1ef1 nhiên ho\u1eb7c sau khi gi\u1ea3m li\u1ec1u t\u1ea1m th\u1eddi. S\u1ef1 xu\u1ea5t hi\u1ec7n các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u1edf h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng có th\u1ec3 là m\u1ed9t bi\u1ec3u hi\u1ec7n c\u1ee7a quá li\u1ec1u t\u01b0\u01a1ng \u0111\u1ed1i ho\u1eb7c nh\u1eefng bi\u1ebfn \u0111\u1ed9ng \u0111áng k\u1ec3 v\u1ec1 các n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng. Trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p này nên theo dõi các n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng.

B\u1ea3ng tóm t\u1eaft các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c t\u1eeb các th\u1eed nghi\u1ec7m lâm sàng và t\u1eeb các báo cáo t\u1ef1 phát

Ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c t\u1eeb các th\u1eed nghi\u1ec7m lâm sàng (B\u1ea3ng 1) \u0111\u01b0\u1ee3c li\u1ec7t kê theo nhóm h\u1ec7 c\u01a1 quan c\u1ee7a MedDRA. Trong m\u1ed7i nhóm h\u1ec7 c\u01a1 quan, các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp theo t\u1ea7n su\u1ea5t, \u0111\u1ea7u tiên là các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i th\u01b0\u1eddng g\u1eb7p nh\u1ea5t. Trong m\u1ed7i nhóm t\u1ea7n su\u1ea5t, các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c trình bày theo th\u1ee9 t\u1ef1 m\u1ee9c \u0111\u1ed9 nghiêm tr\u1ecdng gi\u1ea3m d\u1ea7n. Ngoài ra, lo\u1ea1i t\u1ea7n su\u1ea5t t\u01b0\u01a1ng \u1ee9ng \u0111\u1ed1i v\u1edbi m\u1ed7i ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u0111\u01b0\u1ee3c d\u1ef1a trên quy \u01b0\u1edbc sau \u0111ây (CIOMS III): r\u1ea5t th\u01b0\u1eddng g\u1eb7p (≥1/10); th\u01b0\u1eddng g\u1eb7p ( ≥1/100 \u0111\u1ebfn < 1/10); ít g\u1eb7p (≥1/1.000 \u0111\u1ebfn < 1/100); hi\u1ebfm g\u1eb7p (≥1/10.000 \u0111\u1ebfn < 1/1.000); r\u1ea5t hi\u1ebfm g\u1eb7p ( < 1/10.000).

R\u1ed1i lo\u1ea1n máu và h\u1ec7 b\u1ea1ch huy\u1ebft:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: gi\u1ea3m b\u1ea1ch c\u1ea7u

Th\u01b0\u1eddng g\u1eb7p: gi\u1ea3m ti\u1ec3u c\u1ea7u, t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin

Hi\u1ebfm g\u1eb7p: t\u0103ng b\u1ea1ch c\u1ea7u, b\u1ec7nh h\u1ea1ch b\u1ea1ch huy\u1ebft

R\u1ea5t hi\u1ebfm g\u1eb7p: m\u1ea5t b\u1ea1ch c\u1ea7u h\u1ea1t, thi\u1ebfu máu b\u1ea5t s\u1ea3n, gi\u1ea3m toàn th\u1ec3 huy\u1ebft c\u1ea7u, b\u1ea5t s\u1ea3n \u0111\u01a1n thu\u1ea7n dòng h\u1ed3ng c\u1ea7u, thi\u1ebfu máu, thi\u1ebfu máu nguyên h\u1ed3ng c\u1ea7u kh\u1ed5ng l\u1ed3, t\u0103ng h\u1ed3ng c\u1ea7u l\u01b0\u1edbi, thi\u1ebfu máu tan máu.

R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch:

Hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n quá m\u1eabn ch\u1eadm \u0111a c\u01a1 quan v\u1edbi s\u1ed1t, phát ban, viêm m\u1ea1ch, b\u1ec7nh h\u1ea1ch b\u1ea1ch huy\u1ebft, gi\u1ea3 u lympho, \u0111au kh\u1edbp, gi\u1ea3m b\u1ea1ch c\u1ea7u, t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin, gán lách to, xét nghi\u1ec7m ch\u1ee9c n\u0103ng gan b\u1ea5t th\u01b0\u1eddng và h\u1ed9i ch\u1ee9ng \u1ed1ng m\u1eadt bi\u1ebfn m\u1ea5t (phá h\u1ee7y và bi\u1ebfn m\u1ea5t các ong m\u1eadt trong gan) x\u1ea3y ra trong nhi\u1ec1u s\u1ef1 k\u1ebft h\u1ee3p thu\u1ed1c khác nhau. Các c\u01a1 quan khác c\u0169ngcó th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng (ví d\u1ee5 ph\u1ed5i, th\u1eadn, t\u1ee5y, c\u01a1 tim, \u0111\u1ea1i tràng).

R\u1ea5t hi\u1ebfm g\u1eb7p: ph\u1ea3n \u1ee9ng ph\u1ea3n v\u1ec7, phù m\u1ea1ch, gi\u1ea3m gammaglobulin huy\u1ebft

R\u1ed1i lo\u1ea1n n\u1ed9i ti\u1ebft:

Th\u01b0\u1eddng g\u1eb7p: phù, \u1ee9 d\u1ecbch, t\u0103ng cân, gi\u1ea3m natri huy\u1ebft và gi\u1ea3m áp l\u1ef1c th\u1ea9m th\u1ea5u máu do tác d\u1ee5ng gi\u1ed1ng hormon ch\u1ed1ng bài ni\u1ec7u (ADH) d\u1eabn \u0111\u1ebfn nh\u1eefng tr\u01b0\u1eddng h\u1ee3p hi\u1ebfm g\u1eb7p v\u1edbi ng\u1ed9 \u0111\u1ed9c n\u01b0\u1edbc kèm theo ng\u1ee7 l\u1ecbm, nôn, nh\u1ee9c \u0111\u1ea7u, tình tr\u1ea1ng lú l\u1eabn, các r\u1ed1i lo\u1ea1n th\u1ea7n kinh.

R\u1ea5t hi\u1ebfm g\u1eb7p: ti\u1ebft nhi\u1ec1u s\u1eefa, ch\u1ee9ng vú to \u1edf \u0111àn ông.

R\u1ed1i lo\u1ea1n chuy\u1ec3n hóa và dinh d\u01b0\u1ee1ng:

Hi\u1ebfm g\u1eb7p: thi\u1ebfu h\u1ee5t folate, chán \u0103n

R\u1ea5t hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin c\u1ea5p tính (r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin c\u1ea5p t\u1eebng c\u01a1n và r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin h\u1ed7n h\u1ee3p), r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin không c\u1ea5p tính (r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin bi\u1ec3u hi\u1ec7n da mu\u1ed9n)

R\u1ed1i lo\u1ea1n tâm th\u1ea7n:

Hi\u1ebfm g\u1eb7p: \u1ea3o giác (th\u1ecb giác ho\u1eb7c thính giác), tr\u1ea7m c\u1ea3m, gây h\u1ea5n, kích \u0111\u1ed9ng, b\u1ed3n ch\u1ed3n, tình tr\u1ea1ng lú l\u1eabn

R\u1ea5t hi\u1ebfm g\u1eb7p: kích ho\u1ea1t ch\u1ee9ng lo\u1ea1n tâm th\u1ea7n

R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: m\u1ea5t \u0111i\u1ec1u hòa, chóng m\u1eb7t, bu\u1ed3n ng\u1ee7

Th\u01b0\u1eddng g\u1eb7p: song th\u1ecb, nh\u1ee9c \u0111\u1ea7u

Ít g\u1eb7p: c\u1eed \u0111\u1ed9ng t\u1ef1 ý b\u1ea5t th\u01b0\u1eddng (ví d\u1ee5 run, lo\u1ea1n gi\u1eef t\u01b0 th\u1ebf, lo\u1ea1n tr\u01b0\u01a1ng l\u1ef1c c\u01a1, máy c\u01a1), rung gi\u1eadt nhãn c\u1ea7u

Hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n v\u1eadn \u0111\u1ed9ng, r\u1ed1i lo\u1ea1n c\u1eed \u0111\u1ed9ng m\u1eaft, r\u1ed1i lo\u1ea1n phát âm (ví d\u1ee5 lo\u1ea1n v\u1eadn ngôn, nói l\u1eafp), múa gi\u1ea1t-múa v\u1eddn, b\u1ec7nh th\u1ea7n kinh ngo\u1ea1i biên, d\u1ecb c\u1ea3m, li\u1ec7t nh\u1eb9

R\u1ea5t hi\u1ebfm g\u1eb7p: h\u1ed9i ch\u1ee9ng ác tính do thu\u1ed1c an th\u1ea7n, viêm màng não vô khu\u1ea9n v\u1edbi gi\u1eadt rung c\u01a1 và t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin \u1edf ngo\u1ea1i biên, lo\u1ea1n v\u1ecb giác

R\u1ed1i lo\u1ea1n m\u1eaft:

Th\u01b0\u1eddng g\u1eb7p: r\u1ed1i lo\u1ea1n \u0111i\u1ec1u ti\u1ebft (ví d\u1ee5 nhìn m\u1edd)

R\u1ea5t hi\u1ebfm g\u1eb7p: \u0111\u1ee5c th\u1ee7y tinh th\u1ec3, viêm k\u1ebft m\u1ea1c

R\u1ed1i lo\u1ea1n tai và mê \u0111\u1ea1o

R\u1ea5t hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n thính giác, ví d\u1ee5 ù tai, t\u0103ng thính l\u1ef1c, gi\u1ea3m thính l\u1ef1c, thay \u0111\u1ed5i s\u1ef1 nh\u1eadn bi\u1ebft \u0111\u1ed9 cao c\u1ee7a âm

R\u1ed1i lo\u1ea1n tim:

Hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n d\u1eabn truy\u1ec1n tim

R\u1ea5t hi\u1ebfm g\u1eb7p: lo\u1ea1n nh\u1ecbp, bloc nh\u0129 th\u1ea5t v\u1edbi ng\u1ea5t, nh\u1ecbp tim ch\u1eadm, suy tim sung huy\u1ebft, b\u1ec7nh \u0111\u1ed9ng m\u1ea1ch vành n\u1eb7ng thêm

R\u1ed1i lo\u1ea1n m\u1ea1ch:

Hi\u1ebfm g\u1eb7p: t\u0103ng huy\u1ebft áp ho\u1eb7c h\u1ea1 huy\u1ebft áp

R\u1ea5t hi\u1ebfm g\u1eb7p: tr\u1ee5y tu\u1ea7n hoàn, thuyên t\u1eafc m\u1ea1ch (ví d\u1ee5 thuyên t\u1eafc ph\u1ed5i), viêm t\u0129nh m\u1ea1ch huy\u1ebft kh\u1ed1i.

R\u1ed1i lo\u1ea1n hô h\u1ea5p, ng\u1ef1c và trung th\u1ea5t

R\u1ea5t hi\u1ebfm g\u1eb7p: Quá m\u1eabn ph\u1ed5i \u0111\u1eb7c tr\u01b0ng ví d\u1ee5 b\u1edfi s\u1ed1t, khó th\u1edf, viêm thành ph\u1ebf nang ho\u1eb7c viêm ph\u1ed5i

R\u1ed1i lo\u1ea1n tiêu hóa:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: nôn, buôn nôn

Th\u01b0\u1eddng g\u1eb7p: khô mi\u1ec7ng; kích thích tr\u1ef1c tràng có th\u1ec3 x\u1ea3y ra v\u1edbi d\u1ea1ng thu\u1ed1c \u0111\u1ea1n

Ít g\u1eb7p: tiêu ch\u1ea3y, táo bón

Hi\u1ebfm g\u1eb7p: \u0111au b\u1ee5ng

R\u1ea5t hi\u1ebfm g\u1eb7p: viêm t\u1ee5y, viêm l\u01b0\u1ee1i, viêm mi\u1ec7ng

R\u1ed1i lo\u1ea1n gan m\u1eadt:

Hi\u1ebfm g\u1eb7p: viêm gan \u1ee9 m\u1eadt, viêm nhu mô gan (t\u1ebf bào gan) ho\u1eb7c viêm gan h\u1ed7n h\u1ee3p, h\u1ed9i ch\u1ee9ng \u1ed1ng m\u1eadt bi\u1ebfn m\u1ea5t, vàng da

R\u1ea5t hi\u1ebfm g\u1eb7p: suy gan, b\u1ec7nh gan u h\u1ea1t

R\u1ed1i lo\u1ea1n da và mô d\u01b0\u1edbi da:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: m\u1ec1 \u0111ay có th\u1ec3 nghiêm tr\u1ecdng, viêm da d\u1ecb \u1ee9ng

Ít g\u1eb7p: viêm da tróc v\u1ea3y

Hi\u1ebfm g\u1eb7p: lupus ban \u0111\u1ecf h\u1ec7 th\u1ed1ng, ng\u1ee9a

R\u1ea5t hi\u1ebfm g\u1eb7p: h\u1ed9i ch\u1ee9ng Steven-Johnson*, ho\u1ea1i t\u1eed bi\u1ec3u bì nhi\u1ec5m \u0111\u1ed9c, ph\u1ea3n \u1ee9ng nh\u1ea1y c\u1ea3m ánh sáng, ban \u0111\u1ecf \u0111a d\u1ea1ng, ban \u0111\u1ecf n\u1ed1t, r\u1ed1i lo\u1ea1n s\u1eafc t\u1ed5, ban xu\u1ea5t huy\u1ebft, m\u1ee5n tr\u1ee9ng cá, t\u0103ng ti\u1ebft m\u1ed3 hôi, r\u1ee5ng tóc, r\u1eadm lông

R\u1ed1i lo\u1ea1n h\u1ec7 c\u01a1 x\u01b0\u01a1ng, mô liên k\u1ebft và x\u01b0\u01a1ng:

Hi\u1ebfm g\u1eb7p: y\u1ebfu c\u01a1

R\u1ea5t hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa x\u01b0\u01a1ng (gi\u1ea3m calci trong huy\u1ebft t\u01b0\u01a1ng và g\u1ea3m 25-hydroxy-cholecalciferol trong mau) d\u1eabn \u0111\u1ebfn nhuy\u1ec5n x\u01b0\u01a1ng/loãng x\u01b0\u01a1ng, \u0111au kh\u1edbp, \u0111au c\u01a1, co th\u1eaft c\u01a1

R\u1ed1i lo\u1ea1n th\u1eadn và ti\u1ebft ni\u1ec7u:

R\u1ea5t hi\u1ebfm g\u1eb7p: viêm \u1ed1ng th\u1eadn k\u1ebd, suy th\u1eadn, suy gi\u1ea3m ch\u1ee9c n\u0103ng th\u1eadn (ví d\u1ee5 albumin ni\u1ec7u, huy\u1ebft ni\u1ec7u, thieu ni\u1ec7u và urê huy\u1ebft/nit\u01a1 huy\u1ebft t\u0103ng), bí ti\u1ec3u, ti\u1ec3u nhi\u1ec1u l\u1ea7n

H\u1ec7 sinh s\u1ea3n:

R\u1ea5t hi\u1ebfm g\u1eb7p: r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng tình d\u1ee5c/r\u1ed1i lo\u1ea1n ch\u1ee9c n\u0103ng c\u01b0\u01a1ng, b\u1ea5t th\u01b0\u1eddng v\u1ec1 sinh tinh trùng (v\u1edbi s\u1ed1 l\u01b0\u1ee3ng và/ho\u1eb7c c\u1eed \u0111\u1ed9ng c\u1ee7a tinh trùng gi\u1ea3m)

R\u1ed1i lo\u1ea1n toàn thân và tình tr\u1ea1ng t\u1ea1i ch\u1ed7 dùng thu\u1ed1c:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: m\u1ec7t m\u1ecfi

Xét nghi\u1ec7m:

R\u1ea5t th\u01b0\u1eddng g\u1eb7p: t\u0103ng gamma-glutamyltransferase (do c\u1ea3m \u1ee9ng enzym gan), th\u01b0\u1eddng không có ý ngh\u0129a lâm sàng

Th\u01b0\u1eddng g\u1eb7p: t\u0103ng phosphatase ki\u1ec1m trong máu

Ít g\u1eb7p: t\u0103ng transaminase

R\u1ea5t hi\u1ebfm g\u1eb7p: t\u0103ng áp su\u1ea5t trong m\u1eaft, t\u0103ng cholesterol huy\u1ebft, t\u0103ng lipoprotein t\u1ef7 tr\u1ecdng cao, t\u0103ng triglycerid huy\u1ebft. Xét nghi\u1ec7m ch\u1ee9c n\u0103ng tuy\u1ebfn giáp b\u1ea5t th\u01b0\u1eddng: gi\u1ea3m L-Thyroxin (thyroxin t\u1ef1 do, thyroxin, tri-iodothyronin) và t\u0103ng hormon kích tuy\u1ebfn giáp trong máu, th\u01b0\u1eddng không có bi\u1ec3u hi\u1ec7n lâm sàng, t\u0103ng prolactin huy\u1ebft.

Các ph\u1ea3n \u1ee9ng ph\u1ee5 c\u1ee7a thu\u1ed1c t\u1eeb các báo cáo t\u1ef1 phát (t\u1ea7n su\u1ea5t không rõ)

Các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c sau \u0111ây có ngu\u1ed3n góc t\u1eeb kinh nghi\u1ec7m h\u1eadu mãi v\u1edbi Tegretol thông qua các báo cáo tr\u01b0\u1eddng h\u1ee3p t\u1ef1 phát và các tr\u01b0\u1eddng h\u1ee3p trong y v\u0103n. Vì nh\u1eefng ph\u1ea3n \u1ee9ng này \u0111ã \u0111\u01b0\u1ee3c báo cáo t\u1ef1 nguy\u1ec7n t\u1eeb m\u1ed9t nhóm dân s\u1ed1 có quy mô không xác \u0111\u1ecbnh, không th\u1ec3 \u01b0\u1edbc tính \u0111áng tin c\u1eady v\u1ec1 t\u1ea7n su\u1ea5t, vì v\u1eady \u0111\u01b0\u1ee3c phân lo\u1ea1i là không rõ. Các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i \u0111\u01b0\u1ee3c li\u1ec7t kê theo nhóm h\u1ec7 c\u01a1 quan c\u1ee7a MedDRA. Trong m\u1ed7i nhóm h\u1ec7 c\u01a1 quan, các ph\u1ea3n \u1ee9ng b\u1ea5t l\u1ee3i c\u1ee7a thu\u1ed1c \u0111\u01b0\u1ee3c trình bày theo th\u1ee9 t\u1ef1 m\u1ee9c \u0111\u1ed9 nghiêm tr\u1ecdng gi\u1ea3m d\u1ea7n.

Nhi\u1ec5m trùng và nhi\u1ec5m ký sinh trùng:

Tái ho\u1ea1t nhi\u1ec5m virus herpes 6 \u1edf ng\u01b0\u1eddi

R\u1ed1i lo\u1ea1n máu và h\u1ec7 b\u1ea1ch huy\u1ebft

Suy t\u1ee7y x\u01b0\u01a1ng.

R\u1ed1i lo\u1ea1n h\u1ec7 th\u1ea7n kinh:

Bu\u1ed3n ng\u1ee7, suy gi\u1ea3m trí nh\u1edb.

R\u1ed1i lo\u1ea1n tiêu hóa:

Viêm \u0111\u1ea1i tràng.

R\u1ed1i lo\u1ea1n h\u1ec7 mi\u1ec5n d\u1ecbch:

Phát ban do thu\u1ed1c kèm t\u0103ng b\u1ea1ch c\u1ea7u \u01b0a eosin và các tri\u1ec7u ch\u1ee9ng toàn thân (DRESS).

R\u1ed1i lo\u1ea1n da và mô d\u01b0\u1edbi da:

Phát ban m\u1ee5n m\u1ee7 toàn thân c\u1ea5p tính (AGEP), dày s\u1eebng d\u1ea1ng liken, m\u1ea5t móng.

R\u1ed1i lo\u1ea1n h\u1ec7 c\u01a1 x\u01b0\u01a1ng và mô liên k\u1ebft:

Gãy x\u01b0\u01a1ng.

Xét nghi\u1ec7m:

Gi\u1ea3m m\u1eadt \u0111\u1ed9 x\u01b0\u01a1ng.

Thông báo cho bác s\u0129 nh\u1eefng tác d\u1ee5ng không mong mu\u1ed1n g\u1eb7p ph\u1ea3i khi s\u1eed

d\u1ee5ng thu\u1ed1c.

", "index": 3}, {"title": "Ch\u1ec9 \u0111\u1ecbnh", "content": "

B\u1ec7nh \u0111\u1ed9ng kinh

C\u01a1n \u0111\u1ed9ng kinh c\u1ee5c b\u1ed9 ph\u1ee9c h\u1ee3p ho\u1eb7c \u0111\u01a1n thu\u1ea7n (có ho\u1eb7c không m\u1ea5t ý th\u1ee9c) có ho\u1eb7c không phát tri\u1ec3n toàn th\u1ec3 th\u1ee9 phát.

C\u01a1n \u0111\u1ed9ng kinh co c\u1ee9ng - gi\u1eadt rung phát tri\u1ec3n toàn th\u1ec3. Các d\u1ea1ng \u0111\u1ed9ng kinh h\u1ed7n h\u1ee3p.

Tegretol thích h\u1ee3p cho c\u1ea3 \u0111\u01a1n tr\u1ecb li\u1ec7u và tr\u1ecb li\u1ec7u ph\u1ed1i h\u1ee3p.

Tegretol th\u01b0\u1eddng không hi\u1ec7u qu\u1ea3 trong c\u01a1n v\u1eafng ý th\u1ee9c (\u0111\u1ed9ng kinh c\u01a1n nh\u1ecf) và c\u01a1n \u0111\u1ed9ng kinh gi\u1eadt rung c\u01a1.

C\u01a1n h\u01b0ng c\u1ea3m c\u1ea5p và \u0111i\u1ec3u tr\u1ecb duy trì các r\u1ed1i lo\u1ea1n c\u1ea3m xúc l\u01b0\u1ee1ng c\u1ef1c \u0111\u1ec3 phòng ng\u1eeba ho\u1eb7c làm gi\u1ea3m s\u1ef1 tái phát.

H\u1ed9i ch\u1ee9ng cai r\u01b0\u1ee3u.

\u0110au dây th\u1ea7n kinh sinh ba t\u1ef1 phát và \u0111au dây th\u1ea7n kinh sinh ba do b\u1ec7nh x\u01a1 c\u1ee9ng r\u1ea3i rác (\u0111i\u1ec3n hình ho\u1eb7c không \u0111i\u1ec3n hình). \u0110au dây th\u1ea7n kinh l\u01b0\u1ee1i-h\u1ea7u t\u1ef1 phát.

B\u1ec7nh th\u1ea7n kinh do \u0111ái tháo \u0111\u01b0\u1eddng gây \u0111au.

\u0110ái tháo nh\u1ea1t trung \u01b0\u01a1ng. \u0110a ni\u1ec7u và khát nhi\u1ec1u có ngu\u1ed3n g\u1ed1c hormon th\u1ea7n kinh.

", "index": 4}, {"title": "Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh", "content": "

\u0110ã bi\u1ebft quá m\u1eabn v\u1edbi carbamazepine ho\u1eb7c các thu\u1ed1c có liên quan v\u1ec1 c\u1ea5u trúc (ví d\u1ee5 thu\u1ed1c ch\u1ed1ng tr\u1ea7m c\u1ea3m 3 vòng) ho\u1eb7c v\u1edbi b\u1ea5t k\u1ef3 thành ph\u1ea7n nào c\u1ee7a thu\u1ed1c.

B\u1ec7nh nhân b\u1ecb bloc nh\u0129 th\u1ea5t

B\u1ec7nh nhân có ti\u1ec1n s\u1eed suy t\u1ee7y x\u01b0\u01a1ng

B\u1ec7nh nhân có ti\u1ec1n s\u1eed r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin gan (ví d\u1ee5 r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin c\u1ea5p t\u1eebng c\u01a1n, r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin h\u1ed7n h\u1ee3p, r\u1ed1i lo\u1ea1n chuy\u1ec3n hóa porphyrin bi\u1ec3u hi\u1ec7n da mu\u1ed9n).

Ch\u1ed1ng ch\u1ec9 \u0111\u1ecbnh s\u1eed d\u1ee5ng Tegretol k\u1ebft h\u1ee3p v\u1edbi thu\u1ed1c \u1ee9c ch\u1ebf monoamine - oxidase (MAOI).

", "index": 5}, {"title": "Li\u1ec1u d\u00f9ng", "content": "

B\u1ec7nh \u0111\u1ed9ng kinh.

Khi có th\u1ec3, nên kê \u0111\u01a1n Tegretol d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u.

Nên b\u1ea5t \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi li\u1ec1u th\u1ea5p m\u1ed7i ngày, t\u0103ng t\u1eeb t\u1eeb cho \u0111\u1ebfn khi \u0111\u1ea1t \u0111\u01b0\u1ee3c

hi\u1ec7u qu\u1ea3 t\u1ed1i \u01b0u.

Nên \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u carbamazepine theo nhu c\u1ea7u c\u1ee7a t\u1eebng b\u1ec7nh nhân \u0111\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c s\u1ef1 ki\u1ec3m soát \u0111\u1ea7y \u0111\u1ee7 các c\u01a1n \u0111\u1ed9ng kinh. Xác \u0111\u1ecbnh n\u1ed3ng \u0111\u1ed9 trong huy\u1ebft t\u01b0\u01a1ng có th\u1ec3 giúp xác \u0111\u1ecbnh li\u1ec1u t\u1ed1i \u01b0u.Trong \u0111i\u1ec1u tr\u1ecb b\u1ec7nh \u0111\u1ed9ng kinh, li\u1ec1u carbamazepine th\u01b0\u1eddng \u0111òi h\u1ecfi t\u1ed5ng n\u1ed3ng \u0111\u1ed9 carbamazepine trong huy\u1ebft t\u01b0\u01a1ng kho\u1ea3ng 4 - 12microgam/ml (17 - 50micromol/lít).

Khi c\u1ed9ng thêm Tegretol vào \u0111i\u1ec1u tr\u1ecb ch\u1ed1ng \u0111\u1ed9ng kinh \u0111ang dùng, nên th\u1ef1c hi\u1ec7n \u0111i\u1ec1u này t\u1eeb t\u1eeb trong khi duy trì, ho\u1eb7c n\u1ebfu c\u1ea7n thi\u1ebft, \u0111i\u1ec1u ch\u1ec9nh li\u1ec1u c\u1ee7a thu\u1ed1c ch\u1ed1ng \u0111\u1ed9ng kinh khác.

Nhóm b\u1ec7nh nhân m\u1ee5c tiêu nói chung / Ng\u01b0\u1eddi l\u1edbn

Li\u1ec1u dùng trong b\u1ec7nh \u0111\u1ed9ng kinh

Các d\u1ea1ng u\u1ed1ng

Kh\u1edfi \u0111\u1ea7u dùng 100mg \u0111\u1ebfn 200mg, 1 l\u1ea7n ho\u1eb7c 2 l\u1ea7n/ngày; nên t\u0103ng li\u1ec1u dùng t\u1eeb t\u1eeb - nói chung \u1edf m\u1ee9c 400mg, 2 - 3 l\u1ea7n/ngày - cho \u0111\u1ebfn khi \u0111\u1ea1t \u0111\u01b0\u1ee3c \u0111áp \u1ee9ng t\u1ed1i \u01b0u. \u1ede m\u1ed9t s\u1ed1 b\u1ec7nh nhân, li\u1ec1u 1600mg ho\u1eb7c ngay c\u1ea3 2000mg/ngày có th\u1ec3 thích h\u1ee3p.

Thu\u1ed1c \u0111\u1ea1n

Khi s\u1eed d\u1ee5ng d\u1ea1ng thu\u1ed1c \u0111\u1ea1n thay cho các d\u1ea1ng u\u1ed1ng, li\u1ec1u t\u1ed1i \u0111a hàng ngày \u0111\u01b0\u1ee3c gi\u1edbi h\u1ea1n ch\u1ec9 \u0111\u1ebfn 1000mg (250mg, 4 l\u1ea9n/ngày, cách nhau 6 gi\u1edd).

Hi\u1ec7n ch\u01b0a có d\u1eef li\u1ec7u lâm sàng v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c \u0111\u1ea1n trong các ch\u1ec9 \u0111\u1ecbnh khác ngoài b\u1ec7nh \u0111\u1ed9ng kinh.

Li\u1ec1u dùng trong c\u01a1n h\u01b0ng c\u1ea3m c\u1ea5p và \u0111i\u1ec1u tr\u1ecb duy trì các r\u1ed1i lo\u1ea1n c\u1ea3m xúc l\u01b0\u1ee1ng c\u1ef1c

M\u1ee9c li\u1ec1u: kho\u1ea3ng 400 - 1600mg/ngày, li\u1ec1u dùng thông th\u01b0\u1eddng là 400 - 600mg/ngày chia làm 2 - 3 l\u1ea7n. Trong c\u01a1n h\u01b0ng c\u1ea3m c\u1ea5p, nên t\u0103ng li\u1ec1u khá nhanh, trong khi khuy\u1ebfn cáo dùng t\u1eebng li\u1ec1u t\u0103ng nh\u1ecf trong \u0111i\u1ec1u tr\u1ecb duy trì các r\u1ed1i lo\u1ea1n l\u01b0\u1ee1ng c\u1ef1c \u0111\u1ec3 b\u1ea3o \u0111\u1ea3m s\u1ef1 dung n\u1ea1p t\u1ed1i \u01b0u.

Li\u1ec1u dùng trong h\u1ed9i ch\u1ee9ng cai r\u01b0\u1ee3u

Li\u1ec1u trung bình: 200mg, 3 l\u1ea7n/ngày. Trong tr\u01b0\u1eddng h\u1ee3p n\u1eb7ng li\u1ec1u có th\u1ec3 t\u0103ng lên trong vài ngày \u0111\u1ea7u (ví d\u1ee5 \u0111\u1ebfn 400mg, 3 l\u1ea7n/ngày). Lúc b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb các bi\u1ec3u hi\u1ec7n n\u1eb7ng do cai r\u01b0\u1ee3u, nên k\u1ebft h\u1ee3p Tegretol v\u1edbi các thu\u1ed1c an th\u1ea7n - gây ng\u1ee7 (ví d\u1ee5 clomethiazol, chlordiazepoxid). Sau khi giai \u0111o\u1ea1n c\u1ea5p \u0111ã gi\u1ea3m, có th\u1ec3 ti\u1ebfp t\u1ee5c dùng Tegretol d\u01b0\u1edbi d\u1ea1ng \u0111\u01a1n tr\u1ecb li\u1ec7u.

Li\u1ec1u dùng trong \u0111au dây th\u1ea7n kinh sinh ba

Li\u1ec1u kh\u1edfi \u0111\u1ea7u 200 - 400mg nên t\u0103ng t\u1eeb t\u1eeb m\u1ed7i ngày cho \u0111\u1ebfn khi h\u1ebft \u0111au (thông th\u01b0\u1eddng là 200mg, 3 - 4 l\u1ea7n/ngày). Sau \u0111ó nên gi\u1ea3m li\u1ec1u d\u1ea7n cho \u0111\u1ebfn m\u1ee9c li\u1ec1u duy trì th\u1ea5p nh\u1ea5t có th\u1ec3 \u0111\u01b0\u1ee3c. Li\u1ec1u t\u1ed1i \u0111a \u0111\u01b0\u1ee3c khuy\u1ebfn cáo là 1200mg/ngày. Khi \u0111ã \u0111\u1ea1t \u0111\u01b0\u1ee3c gi\u1ea3m \u0111au, nên c\u1ed1 g\u1eafng ng\u1eebng \u0111i\u1ec1u tr\u1ecb d\u1ea7n d\u1ea7n, cho \u0111\u1ebfn khi c\u01a1n \u0111au khác x\u1ea3y ra.

Li\u1ec1u dùng trong b\u1ec7nh th\u1ea7n kinh do \u0111ái tháo \u0111\u01b0\u1eddng gây \u0111au

Li\u1ec1u trung bình: 200mg, 2 - 4 l\u1ea7n/ngày.

Li\u1ec1u dùng trong \u0111ái tháo nh\u1ea1t trung \u01b0\u01a1ng

Li\u1ec1u trung bình cho ng\u01b0\u1eddi l\u1edbn: 200mg, 2 - 3 l\u1ea7n/ngày. \u1ede tr\u1ebb em nên gi\u1ea3m li\u1ec1u t\u01b0\u01a1ng \u1ee9ng v\u1edbi tu\u1ed5i và th\u1ec3 tr\u1ecdng c\u1ee7a tr\u1ebb.

Các nhóm b\u1ec7nh nhân \u0111\u1eb7c bi\u1ec7t

Suy th\u1eadn / Suy gan

Hi\u1ec7n không có d\u1eef li\u1ec7u v\u1ec1 d\u01b0\u1ee3c \u0111\u1ed9ng h\u1ecdc c\u1ee7a carbamazepine \u1edf b\u1ec7nh nhân suy ch\u1ee9c n\u0103ng gan ho\u1eb7c suy ch\u1ee9c n\u0103ng th\u1eadn.

B\u1ec7nh nhi / Tr\u1ebb em và thi\u1ebfu niên

Li\u1ec1u dùng trong b\u1ec7nh \u0111\u1ed9ng kinh

Các d\u1ea1ng u\u1ed1ng

\u0110\u1ed1i v\u1edbi tr\u1ebb em t\u1eeb 4 tu\u1ed5i tr\u1edf xu\u1ed1ng, khuy\u1ebfn cáo dùng li\u1ec1u kh\u1edfi \u0111\u1ea7u 20 - 60mg/ngày, t\u0103ng lên t\u1eebng 20mg \u0111\u1ebfn 60mg, 2 ngày m\u1ed9t l\u1ea7n. \u0110\u1ed1i v\u1edbi tr\u1ebb em trên 4 tu\u1ed5i, có th\u1ec3 b\u1eaft \u0111\u1ea7u \u0111i\u1ec1u tr\u1ecb v\u1edbi 100mg/ngày, t\u0103ng lên t\u1eebng 100mg cách nhau m\u1ed7i tu\u1ea7n.

Li\u1ec1u duy trì: 10 - 20mg/kg th\u1ec3 tr\u1ecdng/ngày chia làm nhi\u1ec1u l\u1ea7n, ví d\u1ee5:

D\u01b0\u1edbi 1 tu\u1ed5i: 100 - 200mg/ngày (= 5 - 10ml = 1 - 2 \u0111\u01a1n v\u1ecb \u0111ong h\u1ed7n d\u1ecbch u\u1ed1ng)

1 - 5 tu\u1ed5i: 200 - 400mg/ngày (= 10 - 20ml = 2 x 1 - 2 \u0111\u01a1n v\u1ecb \u0111ong h\u1ed7n d\u1ecbch u\u1ed1ng)

6 - 10 tu\u1ed5i: 400 - 600mg/ngày (= 20 - 30ml = 2 - 3 x 2 \u0111\u01a1n v\u1ecb \u0111ong h\u1ed7n d\u1ecbch u\u1ed1ng)

11 - 15 tu\u1ed5i: 600 -1000mg/ngày (= 30 - 50ml = 3 x 2 - 3 \u0111\u01a1n v\u1ecb \u0111ong h\u1ed7n d\u1ecbch u\u1ed1ng)

(thêm m\u1ed9t \u0111\u01a1n v\u1ecb \u0111ong 5ml trong tr\u01b0\u1eddng h\u1ee3p dùng 1000mg)